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Wang J; Xiong Z; Zhang S; Wang Y.
[Engineering MEP pathway in Escherichia coli for amorphadiene production and optimizing the bioprocess through glucose feeding control].
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Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Wu T; Wu S; Yin Q; Dai H; Li S; Dong F; Chen B; Fang H.
[Biosynthesis of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli through introducing mevalonate pathway].
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Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Shen J; Zheng H; Zhi X; Shi Y; Huang Y; Wang W; Chen Y; Kong J; Zhu P.
Improvement of amorpha-4,11-diene production by a yeast-conform variant of Vitreoscilla hemoglobin.
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Zeitschrift fur Naturforschung. C, Journal of biosciences
Kong JQ; Shen JH; Huang Y; Wang W; Cheng KD; Zhu P.
[Production of amorpha-4,11-diene in engineered yeasts].
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Yao xue xue bao = Acta pharmaceutica Sinica
Kong JQ; Cheng KD; Wang LN; Zheng XD; Dai JG; Zhu P; Wang W.
[Increase of copy number of HMG-CoA reductase and FPP synthase genes improves the amorpha4,11-diene production in engineered yeast].
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Yao xue xue bao = Acta pharmaceutica Sinica
Chen X; Zhang C; Zou R; Stephanopoulos G; Too HP.
In Vitro Metabolic Engineering of Amorpha-4,11-diene Biosynthesis at Enhanced Rate and Specific Yield of Production.
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ACS synthetic biology
[DOI: 10.1021/acssynbio.6b00377]
Fang X; Li JX; Huang JQ; Xiao YL; Zhang P; Chen XY.
Systematic identification of functional residues of <i>Artemisia annua</i> amorpha-4,11-diene synthase.
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The Biochemical journal
[DOI: 10.1042/BCJ20170060]
Zhang C; Chen X; Stephanopoulos G; Too HP.
Efflux transporter engineering markedly improves amorphadiene production in Escherichia coli.
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Biotechnology and bioengineering
[DOI: 10.1002/bit.25943]
Li Z; Gao R; Hao Q; Zhao H; Cheng L; He F; Liu L; Liu X; Chou WK; Zhu H; Cane DE.
The T296V Mutant of Amorpha-4,11-diene Synthase Is Defective in Allylic Diphosphate Isomerization but Retains the Ability To Cyclize the Intermediate (3R)-Nerolidyl Diphosphate to Amorpha-4,11-diene.
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Biochemistry
[DOI: 10.1021/acs.biochem.6b01004]
Abdallah II; Czepnik M; van Merkerk R; Quax WJ.
Insights into the Three-Dimensional Structure of Amorpha-4,11-diene Synthase and Probing of Plasticity Residues.
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Journal of natural products
[DOI: 10.1021/acs.jnatprod.6b00236]
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