ChemSpider 2D Image | API-1 | C13H15N5O6

API-1

  • Molecular FormulaC13H15N5O6
  • Average mass337.288 Da
  • Monoisotopic mass337.102234 Da
  • ChemSpider ID25069985

  • defined stereocentres - 4 of 4 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

36707-00-3 [RN]
4-Amino-5,8-dihydro-5-oxo-8-b-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide
4-Amino-5-oxo-8-(β-D-ribofuranosyl)-5,8-dihydropyrido[2,3-d]pyrimidin-6-carboxamid [German] [ACD/IUPAC Name]
4-Amino-5-oxo-8-(β-D-ribofuranosyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide [ACD/IUPAC Name]
4-Amino-5-oxo-8-(β-D-ribofuranosyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide [French] [ACD/IUPAC Name]
4-amino-8-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxo-5H,8H-pyrido[2,3-d]pyrimidine-6-carboxamide
4-amino-8-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
API-1
MFCD18086904
NSC 177223
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

NSC177223 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Akt (Protein Kinase B) Tocris Bioscience 3897
      Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growt h arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo. Tocris Bioscience 3897
      Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo. Tocris Bioscience 3897
      Enzymes Tocris Bioscience 3897
      Kinases Tocris Bioscience 3897
      Selective Akt/PKB inhibitor. Antitumor Tocris Bioscience 3897

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.8±0.1 g/cm3
Boiling Point: 795.8±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.9 mmHg at 25°C
Enthalpy of Vaporization: 121.4±3.0 kJ/mol
Flash Point: 435.1±32.9 °C
Index of Refraction: 1.764
Molar Refractivity: 77.8±0.3 cm3
#H bond acceptors: 11
#H bond donors: 7
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 2
ACD/LogP: -2.57
ACD/LogD (pH 5.5): -2.33
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.28
ACD/LogD (pH 7.4): -2.33
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.28
Polar Surface Area: 185 Å2
Polarizability: 30.8±0.5 10-24cm3
Surface Tension: 130.4±3.0 dyne/cm
Molar Volume: 188.2±3.0 cm3

Click to predict properties on the Chemicalize site


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