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6Substituted 2-aminonicotinamides in the synthesis of pyrido[2,3-d]pyrimidin-4(1H)-ones, 2,3-dihydropyrido- [2,3-d]pyrimidin-4(1H)-ones, and 11b,12-dihydropyrido- [2',3':4,5]pyrimido[2,1-a]isoindole-5,7-diones, Chemistry of Heterocyclic Compounds Reactions of nucleophilic substitution of 4-aryl-5-carbomethoxy-6-methyl-2-chloro-3-cyanopyridines, Chemistry of Heterocyclic Compounds Synthesis and biological activity of substituted 2-chloro- and 2-aminonicotinamides, Pharmaceutical Chemistry Journal